Human Sera
Cayman Chemical IrsogladInmaleate 50mg
A fluorogenic substrate forBgalactosidase cleaved byBgalactosidase to release the fluorescent moiety resorufin ex/em 570/580 nm respectively
Cayman Chemical SulfaclozInsodIum salt 100mg
A compound with anesthetic activity increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices at 100 M induces loss of righting reflex in tadpoles (EC50 0 53 M)
Cayman Chemical trns-ZeatIn RIbosIde 100mg
An inhibitor of EAAT2 (Ki 23 UM) selective for EAAT2 over EAAT1 and EAAT3 (Ki 3 mM for both) reduces depressive-like behavior in rats in the forced swim test at 5 nmol infused into the infralimbic cortex induces anhedonia-like behavior in rats in a sucrose intake test at 6 25 nmol infused into the PFC impairs memory acquisition consolidation and retrieval in mice in the novel object recognition test
Cayman Chemical ArachIdIc AcIdodIum salt 100mg
A PARP inhibitor (IC50 0 2 and 0 24 UM for PARP1 and PARP2 respectively in nuclear rat brain extracts) selective for PARP over GAPDH ADH or LDH has no effect on lipid peroxidation prevents cell death in vitro and in vivo
Cayman Chemical IsotretInoIn 50mg
A polyketide that serves as a precursor for many different antibiotic and anticancer agents
Cayman Chemical VulpInIc AcId 100mg
A lignan with diverse biological activities inhibits polymerization of isolated chicken brain tubulin (IC50 0 6 UM) induces mitotic arrest at the G2/M phase in CCRF CEM cells from 0 01 to 5 Ug/ml is protective against HSV-1 infection in Vero cells at 5 UM inhibits proliferation of several DLBCL cell lines (IC50s 0 0098-0 017 UM) a starting material in the semisynthesis of etoposide and teniposide
Cayman Chemical EsmololhydrochlorIde 100mg
Inhibits necroptosis by blocking MLKL a key substrate of RIP3
Cayman Chemical 2 5-nhydro-D-mnItol 50mg
A benzoxaborole compound that displays broad antifungal effectiveness in vitro inhibits LeuRS from molds and yeasts (IC50s 2 and 4 2 UM for A fumigatus and C albicans LeuRS respectively)
Cayman Chemical IsotretInoIn 100mg
Inhibits BMP type I receptor-induced phosphorylation of SMAD1/5/8 (IC50 4 9 nM) shows specificity for ALK1 2 3 and 6 (IC50s 0 8 0 8 5 3 and 16 7 nM respectively) over ALK4 and 5 (IC50s 101 and 350 nM respectively)
Cayman Chemical NaloxonazInhydrochlorIde 50mg
A potent inhibitor of LIMK1 and LIMK2 (IC50s 7 and 8 nM respectively)
Cayman Chemical ButabIndIdeoxalate 50mg
A long-acting broad-spectrum antibiotic that is effective against Gram-positive and Gram-negative bacteria
Cayman Chemical GrazoprevIr 50mg
LRH-1 Reporter Cells are prepared using INDIGOs proprietary CryoMite process This cryo-preservation method yields high cell viability post-thaw and provides the convenience of immediately dispensing healthy division-competent reporter cells into assay plates There is no need for intermediate spin-and-wash steps viability determinations or cell titer adjustments [INDIGO Catalog Nos IB11001-32 IB11001 IB11002]
Cayman Chemical 2AmIno3methylImIdazo4 5f 50mg
An HDAC inhibitor with structural similarities to mocetinostat MS-275 and JNJ-26481585
Cayman Chemical HenIcosnoIc AcId 100mg
An EED protein-protein interaction inhibitor binds to the EED subunit of PRC2 and inhibits H3K27 methylation (Ki 0 4 nM) inhibits H3K27 di- and trimethylation in RD rhabdoid tumor cells (IC50s 390 and 90 nM respectively) reduces tumor volume and intratumor H3K27 trimethylation in a Pfeiffer DLBCL mouse xenograft model at 200 mg/kg